|
KMID : 0350519940470020859
|
|
Journal of Catholic Medical College
1994 Volume.47 No. 2 p.859 ~ p.871
|
|
|
Anatomical Localization of Superior Cervical Ganglion and the Effect of Its Block on Neovascularization of Alkali Wounded Cornea in Rabbits
|
|
|
|
|
Abstract
|
|
|
The indications of stellate ganglion block(SGB) have been extended to disease of retina and some clinical cases were recently reported. This study was planned to examine the effect of superior cervical ganlion block on neovascularization of
alkali-wounded cornea in rabbits and anatomical localization of superior cervical ganglion radiographically. Twenty rabbits were evenly divided into experimental and contol group. Plain neck lateral radiography and CT scan with radiopaque
contrast
media
showed that the tip of needle punctured through inferior pole of thyroid cartilage that was located at the level of the transverse process of the first cervical vertebra. The blockade of superior cervical ganglion was confirmed by temperature
change of
ear skin and by digital infrared thermal imaging system.
Corneal wound was made by laying 1M NaOH-soaked filter paper disc on upper margin of cornea for 60 seconds in one eye of rabbits and the same side of superior cervical ganglion of experimental group was blocked with 99% alcohol. Gross findings
including
neovascularization of cornea were observed every 5 days interval and pathologic changes of cornea were examined under light microscope at day 20 after alkali wound was made.
@ES The results were summerized as follows ;
@EN 1. The temperature of the ear skin was significantly increased from 36.6±0.7℃ to 37.2±0.7℃ after ganglion block(P<0.05) and thermographic patterns showed asymmetry on digital infrared thermal imaging system.
2. Superior cervical ganglion was located in from of the transverse process of the first cervical vertebra and radiopaque contrast media was distributed from base of skull to the lower margin of second cervical vertebra.
3. Most of new vessels were noted in anterior corneal stroma(P<0.001).
4. The total area of neovascularization of cornea was smaller in experimental group than in control group(P<0.05). The neovascularization was significantly incresed in both groups until 15th days(P<0.001). However the progression of vascular
ingrowth
was stabilized both in the experimental and control group during the 15th to 20th days interval.
The results of this study suggest that superior cervical ganglion block could be used as one of the early preventive measures of neovascularization in alkali wounded cornea of rabbits.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|